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Neurochem Res (2017) 42(8):232635

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For example, the variant 677T is most commonly associated with cerebral vascular accident (stroke), elevated homocysteine, cardiovascular disease risk, peripheral neuropathy, deep vein thrombosis, early-onset heart disease, stillbirth, neuro-tube defect, cleft lip, and preeclampsia

The radioiodinated form of this molecule, I-NDP-alpha-MSH, is the standard displacement radioligand for the whole receptor family, which is why it appears throughout melanocortin binding literature