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CKD is caused by many heterogeneous diseases that are mediated through different pathways, and CKD induces irreversible changes and persistent damage to renal function and structure within months or years
[3] The FOXO4-DRI peptide appears to prevent FOXO4-p53 interaction
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References Alisi A, Piemonte F, Pastore A, Panera N, Passarelli C, Tozzi G, Petrini S, Pietrobattista A, Bottazzo GF, Nobili V (2009) Glutathionylation of p65NF-kappaB correlates with proliferating/apoptotic hepatoma cells exposed to pro- and anti-oxidants
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