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The decline of estrogen and progesterone withdraws hormonal signals that had been governing cellular energy regulation, mitochondrial function, and inflammatory tone across the brain, vasculature, adipose tissue, and skeletal muscle simultaneously

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They can also cause rare and occasionally severe side effects including acute pancreatitis and acute gallbladder diseases as well as intestinal obstruction and gastroparesis

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The NHS Diabetic Eye Screening Programme provides annual screening for all people with diabetes aged 12 and over