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time of day is flexible as absorption is not affected by food intake

"Obesity is a chronic condition and thus requires long-term treatment," says Shalev, who believes the field is moving toward a two-step approach: using a GLP-1 to achieve weight loss, followed by a different medication to help maintain it

Patients with reduced GLP-1R sensitivity often need stronger or more continuous dosing to prevent rebound

Key Benefits Glycemic Control Stimulates insulin secretion in a glucose-dependent manner Reduces inappropriate glucagon levels Improves insulin sensitivity and beta-cell function Controls both fasting and postprandial glucose Weight Management Reduces appetite and food intake Enhances satiety and reduces cravings Activates thermogenesis through glucagon signaling Supports substantial and sustained fat loss Cardiovascular & Metabolic Health Improves lipid profiles (triglycerides, LDL cholesterol) Potentially reduces cardiovascular risk factors Supports liver fat reduction in metabolic-associated fatty liver disease (MAFLD) Dosage & Administration Formulation: 20mg prefilled disposable injection pen with 3ml cartridge Route: Subcutaneous injection Frequency: Once weekly Recommended Dosage Schedule The 20mg pen allows flexible dosing to meet individual treatment goals in both diabetes and obesity management protocols