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This was particularly evident when comparing the maximal response across the different receptors (Supplementary Fig

However, annual growth has slowed, indicating that investments in drug development are outpacing new approvals

Clinical practice guidelines[20, 21] have recommended the use of SGLT2i in individuals at higher risk of HF, while GLP-1RA may be prioritized in those with T2DM at higher ASCVD risk (calculated 10-year ASCVD risk 10%, Class IIa, level of evidence: B) given their neutral effect on HF hospitalization [22]

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