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Biosynthesis runs through two ATP-dependent steps, glutamate-cysteine ligase (EC 6.3.2.2) followed by glutathione synthetase

Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes

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Pattern recognition receptors (PRRs) are cell sensors that recognize conserved molecular structures produced by pathogens called pathogen-associated molecular patterns (PAMPs), as well as non-microbial signals (sterile inflammation) triggered by products released from cell or tissue damage, called damage-associated molecular patterns (DAMPs) [27, 28]