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Testing and Diagnosis: A proper B12 deficiency diagnosis should always be confirmed by blood tests, as symptoms alone can be misleading

J Sep Sci

22,23 In patients with a normal or low-normal serum vitamin B 12 level, complete blood count results demonstrating macrocytosis, or suspected clinical manifestations, a serum methylmalonic acid level is an appropriate next step 1,2,6,18 and is a more direct measure of vitamin B 12 's physiologic activity

Vitamin B12 is often recommended for the treatment of anxiety and depression