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Endogenous Glucagon-Like Peptide 1 Controls Endocrine Pancreatic Secretion and Antro-Pyloro-Duodenal Motility in Humans

Introduction Inflammatory Bowel Disease (IBD), a chronic nonspecific intestinal inflammatory disease that generally causes abdominal pain, diarrhea, and bloody stools, displayed its globalization from Western developed regions to newly industrialized countries in the twenty-first century [1]

Reilly, and Xin M

Gradual titration Always start the new GLP-1 medication at a low dose and titrate it up slowly and gradually to minimize the risk of gastrointestinal adverse effects, even if you were previously on a high dose of a GLP-1 medication

Science 368 , 283290 (2020)