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Its non-selectivity, considered a clinical drawback, is a scientific advantage: it allows for the isolation of the relative contributions of each MCR subtype using selective antagonism protocols (HS024, JNJ-10229570, MCL-0129)

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Blocking was carried out in blocking solution (42 ml PTx.2, 3 ml donkey serum, 5 ml dimethylsulfoxide, 0.02% sodium azide) at 37 C for 2 days

titration strategies, GI side effect management) Cell Metabolism (2022) Coskun T, et al