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Gut Dysbiosis, intestinal permeability and constipation may increase endotoxin, microbial metabolites and enterohepatic recirculation
KEAP1/NRF2 mutant cells are protected against cysteine-starvation induced ferroptosis due to elevated GCLC expression and limited glutamate accumulation, and dual targeting of cystine import and GCLC activity can overcome the resistance of NRF2 active cells to ferroptosis (Kang et al., Cell Metab 2021)
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