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For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients
GLP-1s are powerful medications, and many users experience side effects including nausea, constipation, stomach pain, and reflux that can result in a drastically reduced food intake and rapid weight loss
while normal dietary intake is considered safe, the effects of high-dose parenteral administration are less well studied
A single multiplex to detect at once all 7 analytes was not possible
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