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Androgen depletion causes AR gene and/or enhancer amplification, which renders AR more sensitive to lower levels of ligands, and induces somatic mutations that broaden ARs ligand-binding spectrum or turn antagonists into agonists [4, 26, 27]

Why it's included Included for its supportive role in metabolic function and its potential to help ease nausea, which can occur with GLP-1 therapies

Food and Drug Administration [46] have recognized afamelanotide as an orphan drug for the treatment of EPP and congenital erythropoietic porphyria