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Compared with diabetic controls without ligation (DB-Con), DB-Lig mice showed worse glycemic control and more severe pancreatic dysfunction, as demonstrated by random blood glucose, glycated serum protein, intraperitoneal glucose tolerance test (IPGTT), insulin tolerance test (ITT), and pancreatic insulin/glucagon immunofluorescence staining (Fig S7be)
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An important protective role of NRF2 against EtOH-induced oxidative stress and lipotoxicity has been established in in vivo and in vitro studies 47
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