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E -values, following VanderWeele and Dings approach, estimated the minimum strength of association needed by unmeasured confounders to fully explain observed associations, addressing potential biases from unmeasured confounding 53,54

The data they generate, the personal experience of whether migraines improve, worsen, or stay the same, contributes to the collective understanding of this emerging therapeutic area

Then, the SURMOUNT-OSA trial validated clinical experience

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Specifically, mature red blood cells are enucleated, and organelles such as mitochondria are extruded in healthy conditions