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The SURPASS clinical trial programme for tirzepatide demonstrated that gastrointestinal adverse effects were most frequent during dose escalation periods and generally decreased in frequency and severity with continued treatment

Growth hormone is released as part of a normal stress response, and low levels have been reported in people with fibromyalgia

The study included 2539 adults with a body mass index (BMI) of 30 or higher or 27 or higher with weight-related complications

This includes dosing guidance, titration instructions, and best practices for side-effect monitoring

Reconstitution requirements add complexity