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Sourced From: Nature Dozens of new obesity drugs are coming: these are the ones to watch Published on: 12 February 2025 Doi: Authors: E
Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate
Furthermore, our previous research has demonstrated the functional significance of elevated striatal DA
It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent
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