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Activated glucagon receptors increase thermogenesis, the process by which the body generates heat by burning calories
In a randomized, double-blind, placebo-controlled trial, once-weekly exenatide (2 mg) administered for 48 weeks significantly improved motor scores in patients with PD, with benefits sustained even after treatment discontinuation ( Collectively, these findings indicate that incretin mimetics provide neuroprotection extending beyond metabolic regulation by targeting multiple pathogenic processes in PD, including mitochondrial dysfunction, neuroinflammation from oxidative stress, sirtuin dysregulation, insulin resistance, and S toxicity (Figure 2)
Among them are modulation of inflammation, promotion of angiogenesis, enhancement of matrix remodeling and activation of repair-linked transcription programs
10.1530/JOE-21-0194 70 KulkarniA
