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In contrast, modern humans developed unique lifestyles and technologies that enabled an unprecedented extension of lifespan (Figure 2)
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We have chosen prpTDP-43 A315T mice for our analyses, because this mouse model of TDP-43 pathology was generated based on the A315T mutation detected in the TARDP gene of ALS patients, who had TDP-43 pathology in their cortex 19 , and because the mouse model strictly recapitulated many aspects of the disease, including progressive CSMN degeneration 16
GLP-1RAs contribute to improved glycemic control by lowering glycated hemoglobin (HbA1c) and promoting weight loss without causing hypoglycemia, a notable advantage over sulfonylureas and meglitinides
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