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If you stop semaglutide, weight will be regained. Short term use of the drug has not been demonstrated in a clinical trial, so it is likely semaglutide will be a long-term commitment

Nishimura EK, Jordan SA, Oshima H, Yoshida H, Osawa M, Moriyama M, et al

[2] Clinical Trials Doses Across multiple clinical trials, retatrutide was evaluated in varying doses to determine optimal therapeutic windows for both weight loss and glycemic control

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HEK293T cells (obtained from and certified by the Cell Bank at the Chinese Academy of Sciences and confirmed as negative for mycoplasma contamination) were cultured in DMEM supplemented with 10% (v/v) foetal bovine serum, 50 IU mL 1 penicillin and 50 g mL 1 streptomycin