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The boxed warning states that semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Caloric deficit even a mild 300-500 calorie daily deficit dramatically improves outcomes

Wegovy has been supplied as a single-dose prefilled pen and as a FlexTouch device, the higher-strength Wegovy HD presentation exists alongside the standard strengths, and a compounded preparation dispensed by a licensed pharmacy may come as a vial with separate syringes rather than as a pen at all

However, these studies have duration limited to 68 weeks, and long-term safety beyond 1-2 years remains incompletely characterized

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