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doi: 10.1074/jbc.M112.417014 163 MireaA-MTackCJChavakisTJoostenLABToonenEJM

Methylcobalamin in lipo C formulations maintains adequate B12 status during active weight loss, but once injections are discontinued, oral supplementation (1000mcg daily sublingual methylcobalamin) should continue for 812 weeks to prevent rebound deficiency

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Significant weight loss achieved with tirzepatide may indirectly improve cortisol metabolism through reduced adiposity, improved insulin sensitivity, and decreased systemic inflammation

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