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To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

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The peptide's absorption, distribution, metabolism, and excretion (ADME) profile in humans remains unknown, as does its dose-response curve for NO modulation in human vasculature

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