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Request contract samples with clear definitions of success, such as weight loss thresholds, A1C reductions, and deprescription rates, as well as transparent claims-based performance validation

The GLP-1RAs are achieving blockbuster status, meaning a drug that generates yearly sales exceeding one billion dollars for a drug company

A large observational cohort study reported that nearly half of patients discontinued GLP-1 RA therapy within one year, with lower income significantly associated with discontinuation

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Healthcare providers may adjust dosages based on response and tolerance