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In vivo, in conscious swine a model with GH axis pharmacology closely reflective of human GH secretion ipamorelin produced an ED50 of 2.3 0.03 nmol/kg and an Emax of 65 0.2 ng GH/mL plasma, comparable to GHRP-6 (ED50 3.9 1.4 nmol/kg, Emax 74 7 ng/mL) but with substantially superior selectivity
You may also like Product Description PEG-MGF Peptide | Buy PEG-MGF UK | Research Use Only PEG-MGF Pegylated Mechano Growth Factor is a synthetic, PEGylated analogue of the 24-amino acid C-terminal E-domain peptide of IGF-1Ec (Mechano Growth Factor, the human skeletal muscle-specific splice variant of IGF-1 generated by alternative splicing of exon 5 to exon 6 following mechanical overload or muscle injury), conjugated to polyethylene glycol (PEG) via a succinyl linker to extend its in vivo half-life from approximately 57 minutes for native MGF to 2472 hours making it the only research-viable form of the MGF E-peptide for in vivo pharmacokinetic, satellite cell activation, and tissue repair studies and the defining pre-clinical research tool for investigating the distinct, IGF-1 receptor-independent proliferative signalling axis of the MGF E-domain, satellite cell biology, skeletal muscle regeneration, age-related sarcopenia, cardiac protection, neurogenesis, and the broader mechanosensitive arm of the IGF-1 splice variant system
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