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The rate limiting factor is skin irritation & the patients knowledge about how to modulate usage

Rushing & Selim 2019)

Hyaluronic Acid: Supports skin hydration and reduces fine lines

Lung, WAT, testis, and skeletal muscle preferentially rely on salvage and have low expression of proteins involved in the PreissHandler pathway 41 , with the muscle in particular relying on both NRK1 and NRK2 for supporting its mitochondrial metabolism and fiber type composition 42

Once inside the cell, the complex interacts with intracellular copper-responsive pathways which is what enables the downstream gene-modulation effects to translate from topical application into measurable dermal changes