The progressive drying and keratinization of the conjunctiva, particularly on the nasal and temporal conjunctiva, results in the development of irregularly shaped spots termed Bitot (bee toe) spots after the French physician, Pierre Bitot, who first described them
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293,294 Several new RNA therapeutics are in late-stage clinical trials, such as mRNA-1944 (NCT03829384) 295 and NTLA-2001 (NCT06128629)
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