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215 Although both ER-alpha and ER-beta are important for ovarian development and function and cardiovascular protection, ER-alpha is the more prominent mediator of estrogens effects on metabolism and the breasts, uterus, and bones, whereas ER-beta is more involved in mediating nervous system and immune effects of estrogen, and counteracts pro-proliferation signaling by ER-alpha in the breasts and uterus
Rahman MM, Kwon HS, Kim MJ, Go HK, Oak MH, Kim DH
Brain 172 XieB
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