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GOT2 silencing promotes reprogramming of glutamine metabolism and sensitizes hepatocellular carcinoma to glutaminase inhibitors
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The storage location should be dry, cool, and protected from direct sunlight
In cultured cardiomyocytes, overexpression of GPX4 or iron chelation targeting Fe 2+ in mitochondria prevented DOX-induced ferroptosis, suggesting that DOX triggers ferroptosis in mitochondria [58]
If both pivotal trials deliver results as strong as or stronger than TRIUMPH-4, Lilly could submit the NDA as early as Q3 2026 rather than Q4, shaving 1 to 3 months off the timeline
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