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The difference often depends on whether specific beneficial bacteria are supported during this transition Tirzepatide and Zepbound Gut Side Effects Tirzepatide is the active ingredient in Mounjaro, prescribed for type 2 diabetes, and Zepbound, prescribed for chronic weight management

It may be something upstream that is preventing any weight loss medication from working effectively

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It is very plausible that these patients that have poor blood glucose regulation have faults in their upper digestive tract and those bitter receptors and the sweet receptors that are regulating the production of the GIP and the GLP-1 may not be doing their thing properly or the L cells may be receiving the signal but are not healthy enough to produce enough GLP-1