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doi: 10.1016/j.ejim.2019.03.014 10 ChowEClementSGargR

During these first four weeks, most people notice three things

While highly effective for glycemic control and weight loss, some patients report experiencing weakness and fatigue during treatment

Methods Using a subset of Truveta Data, we identified patients with evidence of either a prescription or a prescription filled at a pharmacy for oral semaglutide between December 22, 2025 (FDA approval date) and February 8, 2026

For researchers tracking this space, emerging GLP-1 platforms and products from companies like Thrive , MMIT , and Willow represent the growing ecosystem of GLP-1 delivery platforms and formulations that make accessing these therapies increasingly straightforward