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In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing
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If someone is starting (or considering) these medications, my biggest piece of advice is to work with a dietitian if you can, or at least follow dietitians who understand GLP-1s and arent fear-mongering about them
How often is sermorelin taken if its half-life is so short
A study demonstrated that activation of GLP-1 receptors in the brain led to reduced caloric intake and improved appetite control in both humans and animals
