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The ENDO 2026 study presented by Sainikhil Sontha of Boston University School of Public Health, analyzing Komodo Health data covering millions of GLP-1 users with type 2 diabetes, found that the majority of those who discontinue GLP-1 medications eventually restart, primarily due to weight regain and worsening metabolic markers

Recommendations are always based on your goals, medical history, and whether peptide therapy actually makes sense as part of your overall care, not just because its available

Furthermore, many drugs used to treat diabetes, such as SUs, TZDs, and insulin, are associated with weight gain

Mood Changes: Changes in hormone levels induced by Spironolactone may occasionally impact mood, leading to mood swings or changes in emotional well-being