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Several studies on children who were vitamin B12 deficient have shown significant increase in growth and cognitive scores when supplemented with vitamin B12 (Sheng etal, 2019

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Based on the impact of PfK13 mutations on hemoglobin uptake and GSH levels in the parasite, one can hypothesise that a decrease in redox-active ferrous heme in artemisinin resistant parasites leads to elevated GSH within the cell, potentially making them more tolerant to artemisinin-induced oxidative stress

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