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We defined S to be a factor multiplying the V max values of GCL and GPX representing the activation of GCL and GPX, so S = 1 for males and S = 1.8 for females for average estradiol, since we make a case based on experimental and clinical results that the activation is by 80%

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Oxidative stress occurs when there is an imbalance between excessive reactive oxygen species (ROS) production and/or diminished cellular antioxidant defenses

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