Of those entering the trial, 24 subjects had normal renal function, 12 subjects each had mild, moderate or severe renal impairment based on the Cockcroft-Gault formula, and 11 had ESRD
Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2
It mimics natural appetite-regulating hormones, slowing digestion, reducing hunger, and helping users feel full with smaller meals
Diabetes Metab J 48:354372
Most people experience some side effects, particularly during dose escalations