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Interestingly, maternal IF has been shown to significantly decrease levels of DNA methyltransferase in offspring, suggesting a potential intergenerational impact on DNA methylation dynamics [89]

This process, often termed somatopause, results in a roughly 15% reduction in GH production every decade

doi:10.1080/14992027.2017.1331049

repletion reverses hematologic symptoms within days and neurologic sequelae over weeks, reflecting differential tissue turnover