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Once in circulation, IGF-1 LR3 binds to IGF-1 receptors (IGF-1R) located on muscle, bone, and connective tissues
Research has historically explored its relationship with sleep architecture regulation and hypothalamic signaling cascades
But because unexplained hypercobalaminemia has been consistently associated with an elevated risk of subsequent cancer diagnosis in large population studies, its one of those lab results worth following up on rather than hoping it goes away
Studies suggest it helps the body renew cells and protect DNA from age-related damage
Free Radic Biol Med 131 , 282298, (2018)
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