The two main candidate molecules that fulfill criteria for an incretin are glucagon-like peptide-1 (GLP-1) and Gastric inhibitory peptide (or glucose-dependent insulinotropic polypeptide or GIP)
Seek urgent medical attention (contact 999, NHS 111, or attend A&E) if you experience: Black, tarry stools (melaena) may indicate upper gastrointestinal bleeding Bright red blood in or on stools, particularly if accompanied by dizziness, weakness, or rapid heartbeat Pale or clay-coloured stools with yellowing of skin or eyes (jaundice) potential biliary obstruction or liver dysfunction Severe abdominal pain with stool changes, especially if persistent or worsening Stop your GLP-1 medication and seek urgent medical assessment if you develop symptoms suggestive of pancreatitis (severe, persistent abdominal pain which may radiate to your back, with or without vomiting)
Some cases are mild and pass quickly
Not necessarily every single patient immediately, but anyone with known retinopathy, symptoms, or overdue retinal screening should strongly consider an updated exam
Eaton S, Fukumoto K, Stefanutti G, Spitz L, Zammit VA, Pierro A: Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis