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doi: 10.1016/j.cell.2017.09.021 15 YangWSKimKJGaschlerMMPatelMShchepinovMSStockwellBR

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Recent studies on Long COVID and ME/CFS patients have revealed signs of elevated oxidative stress and aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase, and lipid oxidative damage

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Renault and Chipuk, 2013)