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However, when these cellular defenses become overwhelmed by chronic inflammation, viral persistence, or environmental triggers, they can create symptoms throughout the entire body

Angiocrine hepatocyte growth factor signaling controls physiological organ and body size and dynamic hepatocyte proliferation to prevent liver damage during regeneration

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Nephron Clin Pract 117:c67c73

Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic