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The second barrier to an amylin-analog drug was to extend the half-life relative to the first-generation drug, pramlintide, which is injected 3 times daily
Patch-clamp on pyramidal cells to characterise intrinsic properties (rheobase, adaptation, afterhyperpolarisation)
The skin becomes thinner, more fragile, more prone to cracking
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doi: 10.1002/art.27650 57 MoschovakisGLBubkeAFriedrichsenMRistenpartJBackJWFalkCSet al
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