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Int J Obes 38(5):689697 Aroda VR et al (2023) Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes
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At present, Novo Nordisk has developed injection preparations (Ozempic) and oral preparations (Rybelsus) for semaglutide: Ozempic (semaglutide, injection preparation): is a weekly subcutaneous injection preparation (0.5mg or 1mg), suitable for: (1) as an auxiliary means of diet adjustment and exercise to improve blood sugar control in adult patients with type 2 diabetes (2) It is used for adult patients with type 2 diabetes with cardiovascular disease (CVD) to reduce the risk of major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal heart attack, and non-fatal stroke)
Other findings included: Gallbladder issues (especially with rapid weight loss) Pancreatitis (rare, with unclear causality) Thyroid C-cell hyperplasia (in animals, not seen in humans) Lean mass lossup to 40% of weight lost may be muscle in older adults None of these derailed regulatory approvals
