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Bulk RNA-Seq data for 449 COAD samples were retrieved from the TCGA-COAD cohort ( while clinical and pathological information was obtained from UCSC Xena ( In this study, samples lacking complete clinical pathological data or with survival times of less than 1 month were excluded

1): HLA-A*03:01 (HLA-A3 from hereon), group 1

For proteomics Differentially expressed proteins were determined by applying Permutation Test with unadjusted significance level of p 90% sequence homology with CYPA10

Binding of NADPH to the -subunit reduces the efficacy of this channel in repolarisation of the membrane potential