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[16] [19] Some research suggests these anti-inflammatory effects may occur alongside weight loss, though the relative contributions of direct immunomodulation versus metabolic improvement remain unclear

Through alterations in the circulation and operation of central nervous system neurotransmitters, the gut microbiota can greatly affect the physiology of the hypothalamic-pituitary-thyroid axis

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In a phase 3 clinical trial, orforglipron lowered patients body weight by an average of 12.4 percent (or 27.3 pounds) compared to 0.9 percent (2.2 pounds) in those who took a placebo

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