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When exposed to bile acids, ME-3 survived for 24 hours without significant loss of live bacteria. Thus, Lactobacillus fermentum ME-3 can tolerate exposure to harsh acidity in the stomach as well as exposure to bile acids in the small intestine

The strongest human clinical evidence is for topical use, including the Leyden 2002 photoaging trial and a 2023 NEEL gel topical study reporting an average 28% increase in skin collagen density at 3 months

doi: 10.3390/biom14080978 3 GuoJWLinGQTangXYYaoJYFengCGZuoJPet al

Furthermore, a complete blood cell count (hemogram) was performed within 24 h using an automated counter Cell-Dyn 3700, 12 parameters (Abbott Laboratories, Abbott Park, IL, USA) to assess animal health status, mainly the hemoglobin value

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