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JAK are a part of the JAK/STAT pathway, and this signaling is continuously activated, resulting in the elevated level of MMPs and apoptotic chondrocytes in RA synovial joints (130)

Among these would include mild diarrhea and itching, as well as headaches and nausea

Some side effects you may experience are redness and swelling at the injection site, as well as lightheadedness, dizziness, and headaches