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Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain

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Histone Modifications The histones can be modified in many ways posttranslationally, including acetylation, methylation, citrullination, ubiquitination, phosphorylation, and sumoylation (299, 300)

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It implies a fundamental depletion of beneficial SCFA-producing taxa, creating a permissive environment for systemic inflammation and oxidative stress to accelerate chondrocyte apoptosis