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Some of these compounds not only directly affect TC cells by reducing their viability, proliferation, or their ability to migrate to the metastatic side, but also indirectly affect cancer progression by regulating the secretion of pro-tumorigenic chemokines in the TC microenvironment
J.NealB.BompointS.HeerspinkH
Side effects are common and of concern, though
This study also highlighted a dose-dependent weight loss of up to 17%, significantly higher than the 3% loss observed with placebo [27]
For weight management, NICE (TA664) recommends these medications within specialist weight management services for people with a BMI of at least 35 kg/m (or 32.5 kg/m in people from minority ethnic backgrounds) with non-diabetic hyperglycaemia and a high risk of cardiovascular disease, or a BMI of at least 30 kg/m with type 2 diabetes
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