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Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial
Bladen CL, Salgado D, Monges S et al (2015) The TREAT-NMD DMD Global Database: analysis of more than 7,000 Duchenne muscular dystrophy mutations
To facilitate the CEA, the NNT measures were only estimated for the statistically significant clinical outcomes between study groups: all-cause death (HR [95% CI]: 0.40 [0.18, 0.91]) and hospitalized hypoglycemia (0.43 [0.27, 0.69])
The early response principle is worth repeating here because it has practical value for managing expectations
Somewhat de-risked compared to other clinical stage biotech companies ex-GLP-1
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