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Based on these findings, we hypothesized that DAPA might impede DN progression through modulation of the Nrf2/HO-1 pathway
However, rapid weight loss doesn't just mean losing fat
It is possible that GIP may still be involved in spite of the observations that its actions are impaired in patients with T2DM (42), because it appears that these can be at least partially restored
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The evidence base is primarily observational and retrospective , with limited randomised controlled trial data specifically in post-bariatric populations
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